I le taimi o le faʻamaʻi, o loʻo faʻaogaina e fomaʻi tui monoclonal antibodies (laboratory-produced antibodies) e fesoasoani ai i tagata mamaʻi e tau faʻamaʻi COVID-19. O le taimi nei o loʻo taumafai tagata suʻesuʻe a le UC Davis e fausia ni faʻamaʻi monoclonal e mafai ona fesoasoani e faʻafefe ai tiga masani. O le fa'amoemoe o le atina'eina lea o se fa'ama'i tiga masina ta'i masina e mafai ona sui ai le opioids.
O le poloketi o loʻo taʻitaʻia e Vladimir Yarov-Yarovoi ma James Trimmer, polofesa i le Matagaluega o Physiology ma Biology of Membrane i le Iunivesite o Kalefonia, Davis School of Medicine. Na latou faʻapotopotoina se 'au faʻapitoa e aofia ai le tele o tagata suʻesuʻe lava e tasi o loʻo taumafai e faʻaliliu le tarantula venom i vailaʻau tiga.
I le amataga o lenei tausaga, na maua ai e Yarov-Yarovoy ma Trimmer se fesoasoani $ 1.5 miliona mai le National Institutes of Health's HEAL program, o se taumafaiga malosi e faʻavavevave fofo faʻasaienisi e taofiofia le faʻalavelave opioid a le atunuu.
Ona o tiga tumau, e mafai ona avea tagata ma vaisu i opioids. O le Centers for Disease Control's National Center for Health Statistics e faʻatatauina e 107,622 tagata faʻamaʻi faʻamaʻi faʻamaʻi oti i le Iunaite Setete i le 2021, toeititi 15% sili atu nai lo le 93,655 maliu i le 2020.
"O mea fou talu ai nei i le faʻatulagaina ma le faʻaogaina o le biology - o le faʻaogaina o komepiuta e malamalama ai ma faʻataʻitaʻiina faiga faʻapitoa - ua faʻavaeina le faʻavae mo le faʻaogaina o auala fou mo le fatuina o antibodies e avea ma sui sili ona lelei mo le togafitia o tiga masani," o le tala lea a Yarov. Yarovoy, o le tagata autu na faia le taui Sai.
"O faʻamaʻi faʻamaʻi monoclonal o le vaega sili ona vave faʻatupulaia o le falemaʻi vailaʻau ma ofoina atu le tele o faʻamanuiaga i luga o vailaʻau laiti mole masani," o le tala lea a Trimmer. O vailaʻau mole mole laiti o vailaʻau ia e faigofie ona ulu i sela. E masani ona faʻaaogaina i vailaʻau.
I le gasologa o tausaga, na fausia ai e le fale suesue a Trimmer le faitau afe o monoclonal antibodies eseese mo faamoemoega eseese, ae o le taumafaiga muamua lea e fausia ai se antibody ua fuafuaina e aveese ai le tiga.
E ui lava e foliga mai i le lumanaʻi, ua faʻamaonia e le US Food and Drug Administration ia faʻamaʻi monoclonal mo togafitiga ma le puipuia o migraine. O vailaʻau fou e galue i luga o se porotini e fesoʻotaʻi ma migraine e taʻua o le calcitonin gene-related peptide.
O le poloketi a le UC Davis e ese le sini - auala faʻapitoa ion i sela neura e taʻua o alavai sodium-gated voltage. O ala nei e pei o "pores" i luga o sela neura.
“O sela o neura e nafa ma le auina atu o faailo o tiga i le tino. O alavai o le sodium ion e mafai ona faʻaogaina i sela neura o le faʻauluuluga autu ia o tiga, "o le faʻamatalaga lea a Yarov-Yarovoy. "O la matou sini o le fatuina o antibodies e fusifusia i nei nofoaga faʻasalalau faʻapitoa i le molecular level, faʻalavelave a latou gaioiga ma poloka le tuʻuina atu o faʻailoga tiga."
Na taulaʻi atu le au suʻesuʻe i auala faʻapitoa e tolu o le sodium e fesoʻotaʻi ma le tiga: NaV1.7, NaV1.8, ma NaV1.9.
O la latou sini o le fatuina o antibodies e fetaui ma nei auala, e pei o se ki e tatala ai se loka. O lenei faiga faʻatatau ua mamanuina e poloka ai le tuʻuina atu o faʻailoga o tiga e ala i le ala e aunoa ma le faʻalavelaveina o isi faʻailoga e tuʻuina atu i sela neura.
O le faʻafitauli o le faʻatulagaina o auala e tolu o loʻo latou taumafai e poloka e matua faigata lava.
Ina ia foia lenei faafitauli, latou liliu atu i le Rosetta ma le AlphaFold polokalame. Fa'atasi ai ma Rosetta, o lo'o fa'atupuina e le au su'esu'e ni fa'ata'ita'iga lavelave fa'a porotini ma su'esu'e po'o fea fa'ata'ita'iga e sili ona fetaui mo le NaV1.7, NaV1.8, ma le NaV1.9 neural channels. Faatasi ai ma le AlphaFold, e mafai e tagata suʻesuʻe ona suʻesuʻe tutoʻatasi polotini na atiaʻe e Rosetta.
O le taimi lava na latou iloa ai ni nai polotini folafolaina, na latou faia ni faʻamaʻi e mafai ona faʻataʻitaʻiina i luga o neural tissue na faia i totonu o le fale suʻesuʻe. O tofotofoga faaletagata e tele tausaga e alu ai.
Ae ua fiafia tagata suʻesuʻe e uiga i le gafatia o lenei auala fou. O vaila'au fa'ama'i fa'ama'i (NSAIDs), e pei o le ibuprofen ma le acetaminophen, e tatau ona fa'aaoga fa'atele i le aso e fa'amama ai le tiga. O vailaʻau faʻamaʻi o le opioid e masani ona inu i aso uma ma e ono lamatia ai le faʻamaʻi.
Ae ui i lea, e mafai ona taamilo i totonu o le toto monoclonal antibodies mo le sili atu ma le masina aʻo leʻi faʻaumatia e le tino. Na faʻamoemoe le au suʻesuʻe i tagata mamaʻi e faʻatonuina e le tagata lava ia le analgesic monoclonal antibody faʻatasi i le masina.
"Mo tagata mamaʻi e maua i le tiga tumau, o le mea tonu lava lea e te manaʻomia," o le tala lea a Yarov-Yarovoy. “Latou te oo i le tiga e le mo ni aso, ae mo vaiaso ma masina. O loʻo faʻamoemoeina o le faʻasalalauina o antibodies o le a mafai ona maua ai le toomaga tiga e tumau mo ni nai vaiaso.
O isi sui o le au e aofia ai Bruno Correia o le EPFL, Steven Waxman o Yale, William Schmidt ma Heike Wolf o EicOsis, Bruce Hammock, Teanne Griffith, Karen Wagner, John T. Sack, David J. Copenhaver, Scott Fishman, Daniel J. Tancredi, Hai Nguyen, Phuong Tran Nguyen, Diego Lopez Mateos, ma Robert Stewart o le UC Davis.
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Taimi meli: Sep-29-2022